BRD-A52530684_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-A52530684_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AGA aspartylglucosaminidase
ARMCX2 armadillo repeat containing, X-linked 2
BEX4 brain expressed, X-linked 4
BSG basigin (Ok blood group)
CCNA1 cyclin A1
CCND2 cyclin D2
CD52 CD52 molecule
CD99 CD99 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
COL3A1 collagen, type III, alpha 1
CYBRD1 cytochrome b reductase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ERLIN2 ER lipid raft associated 2
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
NREP neuronal regeneration related protein
NTS neurotensin
PGK1 phosphoglycerate kinase 1
PLVAP plasmalemma vesicle associated protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRSF1 serine/arginine-rich splicing factor 1
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TUBA1A tubulin, alpha 1a
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
AGO2 argonaute RISC catalytic component 2
AHR aryl hydrocarbon receptor
ARF6 ADP-ribosylation factor 6
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
BRIX1 BRX1, biogenesis of ribosomes
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CENPB centromere protein B, 80kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DST dystonin
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FAM208B family with sequence similarity 208, member B
FBL fibrillarin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GEMIN4 gem (nuclear organelle) associated protein 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PTK2 protein tyrosine kinase 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNPS1 RNA binding protein S1, serine-rich domain
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM243 transmembrane protein 243, mitochondrial
TPX2 TPX2, microtubule-associated
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
UMPS uridine monophosphate synthetase
USP22 ubiquitin specific peptidase 22
WAC WW domain containing adaptor with coiled-coil
WDR43 WD repeat domain 43
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZYX zyxin
Funding