BRD-A52530684_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-A52530684_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
BGN biglycan
CA1 carbonic anhydrase I
CALD1 caldesmon 1
CAV2 caveolin 2
CCDC53 coiled-coil domain containing 53
CD302 CD302 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFH complement factor H
CHGB chromogranin B
COCH cochlin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
FGG fibrinogen gamma chain
GJA1 gap junction protein, alpha 1, 43kDa
GNG10 guanine nucleotide binding protein (G protein), gamma 10
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP7 insulin-like growth factor binding protein 7
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
NBR1 neighbor of BRCA1 gene 1
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NPTX2 neuronal pentraxin II
NTS neurotensin
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
VCAN versican

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNF cyclin F
CDC25A cell division cycle 25A
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
CEP350 centrosomal protein 350kDa
CHD7 chromodomain helicase DNA binding protein 7
CHSY1 chondroitin sulfate synthase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRNP2 cysteine-serine-rich nuclear protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
FAM208B family with sequence similarity 208, member B
FEM1B fem-1 homolog b (C. elegans)
FOXJ3 forkhead box J3
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER1 homer scaffolding protein 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM2A lysine (K)-specific demethylase 2A
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MTF2 metal response element binding transcription factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POGK pogo transposable element with KRAB domain
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRDM2 PR domain containing 2, with ZNF domain
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM15 RNA binding motif protein 15
RNF111 ring finger protein 111
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSBN1 round spermatid basic protein 1
RYBP RING1 and YY1 binding protein
SALL1 spalt-like transcription factor 1
SEPHS1 selenophosphate synthetase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SETD5 SET domain containing 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SRSF2 serine/arginine-rich splicing factor 2
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP6NL USP6 N-terminal like
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF281 zinc finger protein 281
Funding