BRD-A55369275_CGP 54626 hydrochloride_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A55369275_CGP 54626 hydrochloride_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD86 CD86 molecule
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL9 chemokine (C-X-C motif) ligand 9
EXT1 exostosin glycosyltransferase 1
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
FMOD fibromodulin
GAGE3 G antigen 3
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL13RA1 interleukin 13 receptor, alpha 1
IL1R2 interleukin 1 receptor, type II
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NDN necdin, melanoma antigen (MAGE) family member
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPTX2 neuronal pentraxin II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRAME preferentially expressed antigen in melanoma
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB1D2 secretoglobin, family 1D, member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX10 sorting nexin 10
SOCS2 suppressor of cytokine signaling 2
SPRED2 sprouty-related, EVH1 domain containing 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIB2 tribbles pseudokinase 2
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AK1 adenylate kinase 1
CD24 CD24 molecule
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTX4 deltex 4, E3 ubiquitin ligase
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENOSF1 enolase superfamily member 1
F2R coagulation factor II (thrombin) receptor
FASN fatty acid synthase
HBB hemoglobin, beta
IGFBP7 insulin-like growth factor binding protein 7
KDM5D lysine (K)-specific demethylase 5D
MAP7 microtubule-associated protein 7
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SYNJ2 synaptojanin 2
TSPO translocator protein (18kDa)
Funding