BRD-A55594068_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A55594068_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AHNAK AHNAK nucleoprotein
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CPM carboxypeptidase M
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DUSP14 dual specificity phosphatase 14
DUSP3 dual specificity phosphatase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM69A family with sequence similarity 69, member A
FHL2 four and a half LIM domains 2
FLG filaggrin
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRAMD3 GRAM domain containing 3
HOPX HOP homeobox
IL1R1 interleukin 1 receptor, type I
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
OXSR1 oxidative stress responsive 1
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PRSS8 protease, serine, 8
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TGFB2 transforming growth factor, beta 2
TXNRD1 thioredoxin reductase 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CCNF cyclin F
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
ITM2A integral membrane protein 2A
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
MARCKSL1 MARCKS-like 1
MIA melanoma inhibitory activity
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRR7 proline rich 7 (synaptic)
RGS1 regulator of G-protein signaling 1
SCG2 secretogranin II
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
TESC tescalcin
THAP11 THAP domain containing 11
TLK2 tousled-like kinase 2
ZMYND8 zinc finger, MYND-type containing 8