BRD-A58767537_afatinib_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-A58767537_afatinib_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
AVPI1 arginine vasopressin-induced 1
BLVRB biliverdin reductase B
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C14ORF159 chromosome 14 open reading frame 159
CAT catalase
CD24 CD24 molecule
CD58 CD58 molecule
CFD complement factor D (adipsin)
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CREG1 cellular repressor of E1A-stimulated genes 1
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
DAPK1 death-associated protein kinase 1
DCN decorin
E2F2 E2F transcription factor 2
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FZD2 frizzled class receptor 2
GAA glucosidase, alpha; acid
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GM2A GM2 ganglioside activator
GRN granulin
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
LAMP2 lysosomal-associated membrane protein 2
LMOD1 leiomodin 1 (smooth muscle)
LOC100505650 uncharacterized LOC100505650
LY6E lymphocyte antigen 6 complex, locus E
MATN2 matrilin 2
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
N4BP2L1 NEDD4 binding protein 2-like 1
NPR3 natriuretic peptide receptor 3
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML1 olfactomedin-like 1
OPN3 opsin 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PHGDH phosphoglycerate dehydrogenase
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRAME preferentially expressed antigen in melanoma
PTEN phosphatase and tensin homolog
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RSAD2 radical S-adenosyl methionine domain containing 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TFEC transcription factor EC
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP63 tumor protein p63
TRAPPC6A trafficking protein particle complex 6A
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)

decreased expression

Symbol Name
ALB albumin
ANXA3 annexin A3
ATG3 autophagy related 3
BCL2A1 BCL2-related protein A1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC42 cell division cycle 42
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EREG epiregulin
ETV1 ets variant 1
G0S2 G0/G1 switch 2
HMGA2 high mobility group AT-hook 2
HP haptoglobin
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRAK1 interleukin-1 receptor-associated kinase 1
LIPG lipase, endothelial
LYZ lysozyme
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
ORM1 orosomucoid 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TF transferrin
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
Funding