| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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120 genes differentially expressed following the BRD-A58767537_afatinib_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABHD4 | abhydrolase domain containing 4 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide |
| ADIRF | adipogenesis regulatory factor |
| AIM1 | absent in melanoma 1 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) |
| ATF3 | activating transcription factor 3 |
| ATXN1 | ataxin 1 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| CAV2 | caveolin 2 |
| CCL19 | chemokine (C-C motif) ligand 19 |
| CCNG2 | cyclin G2 |
| CD99 | CD99 molecule |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CEP57 | centrosomal protein 57kDa |
| CFD | complement factor D (adipsin) |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| CHRDL1 | chordin-like 1 |
| CLU | clusterin |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 |
| CRYAB | crystallin, alpha B |
| CSRP2 | cysteine and glycine-rich protein 2 |
| CTH | cystathionine gamma-lyase |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| DMD | dystrophin |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EFNB2 | ephrin-B2 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| FAM129A | family with sequence similarity 129, member A |
| FGF13 | fibroblast growth factor 13 |
| FHL1 | four and a half LIM domains 1 |
| GATA3 | GATA binding protein 3 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| HSPB8 | heat shock 22kDa protein 8 |
| IRS2 | insulin receptor substrate 2 |
| KRT15 | keratin 15, type I |
| LPL | lipoprotein lipase |
| LY75 | lymphocyte antigen 75 |
| MEF2C | myocyte enhancer factor 2C |
| NEBL | nebulette |
| OSR2 | odd-skipped related transciption factor 2 |
| OXTR | oxytocin receptor |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PLA2G16 | phospholipase A2, group XVI |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
| PSAT1 | phosphoserine aminotransferase 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTN | pleiotrophin |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RGS5 | regulator of G-protein signaling 5 |
| STC2 | stanniocalcin 2 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYNM | synemin, intermediate filament protein |
| TBX2 | T-box 2 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TMEM47 | transmembrane protein 47 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TPD52L1 | tumor protein D52-like 1 |
| TSC22D3 | TSC22 domain family, member 3 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 |
| Symbol | Name |
|---|---|
| AK1 | adenylate kinase 1 |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCL20 | chemokine (C-C motif) ligand 20 |
| CD44 | CD44 molecule (Indian blood group) |
| CHGB | chromogranin B |
| COMP | cartilage oligomeric matrix protein |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP6 | dual specificity phosphatase 6 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| FAP | fibroblast activation protein, alpha |
| FOSL1 | FOS-like antigen 1 |
| GLS | glutaminase |
| GOLGA8A | golgin A8 family, member A |
| GOLGA8B | golgin A8 family, member B |
| HBEGF | heparin-binding EGF-like growth factor |
| HSPA8 | heat shock 70kDa protein 8 |
| IER3 | immediate early response 3 |
| IL1B | interleukin 1, beta |
| INHBA | inhibin, beta A |
| INSM1 | insulinoma-associated 1 |
| LAMC2 | laminin, gamma 2 |
| LAPTM4B | lysosomal protein transmembrane 4 beta |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MMP9 | matrix metallopeptidase 9 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NRG1 | neuregulin 1 |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PI3 | peptidase inhibitor 3, skin-derived |
| PLAU | plasminogen activator, urokinase |
| PLAUR | plasminogen activator, urokinase receptor |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| PRKCD | protein kinase C, delta |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| RAI14 | retinoic acid induced 14 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 |
| SPP1 | secreted phosphoprotein 1 |
| SPRY4 | sprouty homolog 4 (Drosophila) |
| STX1A | syntaxin 1A (brain) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| THBS1 | thrombospondin 1 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TSPAN4 | tetraspanin 4 |
| TXNDC9 | thioredoxin domain containing 9 |
| VEGFA | vascular endothelial growth factor A |
| XIST | X inactive specific transcript (non-protein coding) |
