| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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105 genes differentially expressed following the BRD-A58767537_afatinib_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ACKR3 | atypical chemokine receptor 3 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| C10ORF10 | chromosome 10 open reading frame 10 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| CLU | clusterin |
| CPE | carboxypeptidase E |
| CRYAB | crystallin, alpha B |
| CSRP2 | cysteine and glycine-rich protein 2 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| EPHB2 | EPH receptor B2 |
| FBLN1 | fibulin 1 |
| FBLN2 | fibulin 2 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 |
| FRZB | frizzled-related protein |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GPNMB | glycoprotein (transmembrane) nmb |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| IGKC | immunoglobulin kappa constant |
| IGL | immunoglobulin lambda locus |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) |
| ITM2A | integral membrane protein 2A |
| KLF4 | Kruppel-like factor 4 (gut) |
| KRT17 | keratin 17, type I |
| METTL7A | methyltransferase like 7A |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NEBL | nebulette |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| PDGFD | platelet derived growth factor D |
| PIR | pirin (iron-binding nuclear protein) |
| PLS3 | plastin 3 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
| PSAT1 | phosphoserine aminotransferase 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| RBP1 | retinol binding protein 1, cellular |
| RELN | reelin |
| RSRP1 | arginine/serine-rich protein 1 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
| TFF3 | trefoil factor 3 (intestinal) |
| TSC22D3 | TSC22 domain family, member 3 |
| TSPYL5 | TSPY-like 5 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| XBP1 | X-box binding protein 1 |
| Symbol | Name |
|---|---|
| ANPEP | alanyl (membrane) aminopeptidase |
| AREG | amphiregulin |
| CCNE2 | cyclin E2 |
| CDCP1 | CUB domain containing protein 1 |
| CHGB | chromogranin B |
| CLC | Charcot-Leyden crystal galectin |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DLC1 | DLC1 Rho GTPase activating protein |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| EREG | epiregulin |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| FERMT1 | fermitin family member 1 |
| FOSL1 | FOS-like antigen 1 |
| G0S2 | G0/G1 switch 2 |
| HAS2 | hyaluronan synthase 2 |
| HBEGF | heparin-binding EGF-like growth factor |
| HIST1H4C | histone cluster 1, H4c |
| HMGA2 | high mobility group AT-hook 2 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| IER3 | immediate early response 3 |
| IL1B | interleukin 1, beta |
| LDLR | low density lipoprotein receptor |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MALL | mal, T-cell differentiation protein-like |
| MME | membrane metallo-endopeptidase |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PNP | purine nucleoside phosphorylase |
| PRKCD | protein kinase C, delta |
| PROM1 | prominin 1 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase |
| RRM2 | ribonucleotide reductase M2 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| SFRP1 | secreted frizzled-related protein 1 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 |
| SRPX | sushi-repeat containing protein, X-linked |
| STC1 | stanniocalcin 1 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TGFA | transforming growth factor, alpha |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TOP1 | topoisomerase (DNA) I |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| VCAN | versican |
