| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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337 genes differentially expressed following the BRD-A58767537_afatinib_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ACKR3 | atypical chemokine receptor 3 |
| ADIRF | adipogenesis regulatory factor |
| AHNAK | AHNAK nucleoprotein |
| AHNAK2 | AHNAK nucleoprotein 2 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| ALDOC | aldolase C, fructose-bisphosphate |
| ANGPTL2 | angiopoietin-like 2 |
| ANXA4 | annexin A4 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 |
| ASS1 | argininosuccinate synthase 1 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 |
| BCL6 | B-cell CLL/lymphoma 6 |
| BLNK | B-cell linker |
| BLVRB | biliverdin reductase B |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C1R | complement component 1, r subcomponent |
| C1RL | complement component 1, r subcomponent-like |
| C1S | complement component 1, s subcomponent |
| C3 | complement component 3 |
| C9ORF3 | chromosome 9 open reading frame 3 |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCNG2 | cyclin G2 |
| CD14 | CD14 molecule |
| CD47 | CD47 molecule |
| CDR2L | cerebellar degeneration-related protein 2-like |
| CFB | complement factor B |
| CFD | complement factor D (adipsin) |
| CLDN7 | claudin 7 |
| CLIC5 | chloride intracellular channel 5 |
| CLU | clusterin |
| CP | ceruloplasmin (ferroxidase) |
| CRABP2 | cellular retinoic acid binding protein 2 |
| CRYAB | crystallin, alpha B |
| CTSD | cathepsin D |
| CTSS | cathepsin S |
| DCN | decorin |
| DDR1 | discoidin domain receptor tyrosine kinase 1 |
| DEFB1 | defensin, beta 1 |
| DNASE2 | deoxyribonuclease II, lysosomal |
| DSP | desmoplakin |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
| F13A1 | coagulation factor XIII, A1 polypeptide |
| FABP3 | fatty acid binding protein 3, muscle and heart |
| FBLN1 | fibulin 1 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) |
| FOXO4 | forkhead box O4 |
| GAA | glucosidase, alpha; acid |
| GLUL | glutamate-ammonia ligase |
| GM2A | GM2 ganglioside activator |
| GPM6A | glycoprotein M6A |
| GPM6B | glycoprotein M6B |
| GPNMB | glycoprotein (transmembrane) nmb |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B |
| GPX3 | glutathione peroxidase 3 |
| GRN | granulin |
| GSE1 | Gse1 coiled-coil protein |
| GSN | gelsolin |
| HCAR3 | hydroxycarboxylic acid receptor 3 |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BK | histone cluster 1, H2bk |
| HIST3H2A | histone cluster 3, H2a |
| HLA-E | major histocompatibility complex, class I, E |
| HMOX1 | heme oxygenase 1 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| HSPB8 | heat shock 22kDa protein 8 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IFITM1 | interferon induced transmembrane protein 1 |
| IL1R1 | interleukin 1 receptor, type I |
| ITGB4 | integrin, beta 4 |
| JAM2 | junctional adhesion molecule 2 |
| JUP | junction plakoglobin |
| KLHL24 | kelch-like family member 24 |
| KRT13 | keratin 13, type I |
| KRT19 | keratin 19, type I |
| KRT4 | keratin 4, type II |
| KRT6A | keratin 6A, type II |
| KYNU | kynureninase |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LCN2 | lipocalin 2 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 |
| LRRC16A | leucine rich repeat containing 16A |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 |
| MECOM | MDS1 and EVI1 complex locus |
| METTL7A | methyltransferase like 7A |
| MME | membrane metallo-endopeptidase |
| MMP7 | matrix metallopeptidase 7 |
| MTSS1 | metastasis suppressor 1 |
| MUC1 | mucin 1, cell surface associated |
| MXI1 | MAX interactor 1, dimerization protein |
| MXRA5 | matrix-remodelling associated 5 |
| NDRG1 | N-myc downstream regulated 1 |
| NEBL | nebulette |
| NOV | nephroblastoma overexpressed |
| NRCAM | neuronal cell adhesion molecule |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OPTN | optineurin |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| OSR2 | odd-skipped related transciption factor 2 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| PAM | peptidylglycine alpha-amidating monooxygenase |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDGFD | platelet derived growth factor D |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PERP | PERP, TP53 apoptosis effector |
| PI3 | peptidase inhibitor 3, skin-derived |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PPL | periplakin |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta |
| PROM1 | prominin 1 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| PTPRC | protein tyrosine phosphatase, receptor type, C |
| PYCARD | PYD and CARD domain containing |
| QPRT | quinolinate phosphoribosyltransferase |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RNASET2 | ribonuclease T2 |
| RND3 | Rho family GTPase 3 |
| S100A4 | S100 calcium binding protein A4 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SCPEP1 | serine carboxypeptidase 1 |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SH3YL1 | SH3 and SYLF domain containing 1 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SPATA20 | spermatogenesis associated 20 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 |
| SPON2 | spondin 2, extracellular matrix protein |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 |
| TM7SF2 | transmembrane 7 superfamily member 2 |
| TMEM45A | transmembrane protein 45A |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TNXB | tenascin XB |
| TP53TG1 | TP53 target 1 (non-protein coding) |
| TRIM22 | tripartite motif containing 22 |
| TRIM29 | tripartite motif containing 29 |
| TRIM8 | tripartite motif containing 8 |
| TSC22D3 | TSC22 domain family, member 3 |
| TXNIP | thioredoxin interacting protein |
| UBXN4 | UBX domain protein 4 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| VAV3 | vav 3 guanine nucleotide exchange factor |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 |
| VWA5A | von Willebrand factor A domain containing 5A |
| WFDC2 | WAP four-disulfide core domain 2 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
| XIST | X inactive specific transcript (non-protein coding) |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZSCAN31 | zinc finger and SCAN domain containing 31 |
| Symbol | Name |
|---|---|
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| ANXA3 | annexin A3 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| ASF1B | anti-silencing function 1B histone chaperone |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BRCA1 | breast cancer 1, early onset |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
| CCNA2 | cyclin A2 |
| CCNB2 | cyclin B2 |
| CCND1 | cyclin D1 |
| CCNF | cyclin F |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC6 | cell division cycle 6 |
| CDCA3 | cell division cycle associated 3 |
| CDCA8 | cell division cycle associated 8 |
| CDK1 | cyclin-dependent kinase 1 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPA | centromere protein A |
| CENPF | centromere protein F, 350/400kDa |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CLC | Charcot-Leyden crystal galectin |
| COTL1 | coactosin-like F-actin binding protein 1 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DBF4 | DBF4 zinc finger |
| DCK | deoxycytidine kinase |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DLC1 | DLC1 Rho GTPase activating protein |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 |
| DONSON | downstream neighbor of SON |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| EGR1 | early growth response 1 |
| EGR3 | early growth response 3 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| ETV5 | ets variant 5 |
| EXO1 | exonuclease 1 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FANCG | Fanconi anemia, complementation group G |
| FANCI | Fanconi anemia, complementation group I |
| FEN1 | flap structure-specific endonuclease 1 |
| FKBP11 | FK506 binding protein 11, 19 kDa |
| FOSL1 | FOS-like antigen 1 |
| FOXM1 | forkhead box M1 |
| GAL | galanin/GMAP prepropeptide |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GTSE1 | G-2 and S-phase expressed 1 |
| HBEGF | heparin-binding EGF-like growth factor |
| HIST1H4C | histone cluster 1, H4c |
| HJURP | Holliday junction recognition protein |
| HMGA2 | high mobility group AT-hook 2 |
| HMGB2 | high mobility group box 2 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| IER3 | immediate early response 3 |
| IFRD2 | interferon-related developmental regulator 2 |
| INHBA | inhibin, beta A |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF18B | kinesin family member 18B |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| KIF4A | kinesin family member 4A |
| LBR | lamin B receptor |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MALL | mal, T-cell differentiation protein-like |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MELK | maternal embryonic leucine zipper kinase |
| MIS18A | MIS18 kinetochore protein A |
| MKI67 | marker of proliferation Ki-67 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NAV3 | neuron navigator 3 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NDC80 | NDC80 kinetochore complex component |
| NEK2 | NIMA-related kinase 2 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NOP56 | NOP56 ribonucleoprotein |
| NPY | neuropeptide Y |
| NRG1 | neuregulin 1 |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PCNA | proliferating cell nuclear antigen |
| PHGDH | phosphoglycerate dehydrogenase |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PLK1 | polo-like kinase 1 |
| PNP | purine nucleoside phosphorylase |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| PRC1 | protein regulator of cytokinesis 1 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PSAT1 | phosphoserine aminotransferase 1 |
| PTTG1 | pituitary tumor-transforming 1 |
| RACGAP1 | Rac GTPase activating protein 1 |
| RAD51AP1 | RAD51 associated protein 1 |
| RANBP1 | RAN binding protein 1 |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| SEPT11 | septin 11 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SMC2 | structural maintenance of chromosomes 2 |
| SMC4 | structural maintenance of chromosomes 4 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPDL1 | spindle apparatus coiled-coil protein 1 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SRM | spermidine synthase |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| STMN1 | stathmin 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| THBS1 | thrombospondin 1 |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPRKB | TP53RK binding protein |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TTK | TTK protein kinase |
| TUBB | tubulin, beta class I |
| TUBB4B | tubulin, beta 4B class IVb |
| TYMS | thymidylate synthetase |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UPP1 | uridine phosphorylase 1 |
| USP1 | ubiquitin specific peptidase 1 |
| VIM | vimentin |
| VRK1 | vaccinia related kinase 1 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| ZWINT | ZW10 interacting kinetochore protein |
