BRD-A60414806_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-A60414806_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
ATF3 activating transcription factor 3
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CTSV cathepsin V
CYR61 cysteine-rich, angiogenic inducer, 61
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FHL2 four and a half LIM domains 2
GADD45B growth arrest and DNA-damage-inducible, beta
GRAMD3 GRAM domain containing 3
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BG histone cluster 1, H2bg
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFD platelet derived growth factor D
PKP2 plakophilin 2
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
PROM1 prominin 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS3 transmembrane protease, serine 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CADPS2 Ca++-dependent secretion activator 2
CD24 CD24 molecule
CD48 CD48 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
ERBB3 erb-b2 receptor tyrosine kinase 3
FXYD2 FXYD domain containing ion transport regulator 2
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MIA melanoma inhibitory activity
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
PHLDA1 pleckstrin homology-like domain, family A, member 1
RNF144A ring finger protein 144A
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TSPAN8 tetraspanin 8