BRD-A61825514_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-A61825514_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADM adrenomedullin
APOD apolipoprotein D
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN2A cyclin-dependent kinase inhibitor 2A
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTSG cathepsin G
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPI glucose-6-phosphate isomerase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
LAMB3 laminin, beta 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS8 lectin, galactoside-binding, soluble, 8
MB myoglobin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RALGDS ral guanine nucleotide dissociation stimulator
RGS2 regulator of G-protein signaling 2
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
STC1 stanniocalcin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
BAMBI BMP and activin membrane-bound inhibitor
C3ORF14 chromosome 3 open reading frame 14
CCDC109B coiled-coil domain containing 109B
CD200 CD200 molecule
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GREM1 gremlin 1, DAN family BMP antagonist
ISOC1 isochorismatase domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
POSTN periostin, osteoblast specific factor
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
VCAN versican
Funding