BRD-A61825514_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A61825514_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSL5 acyl-CoA synthetase long-chain family member 5
ADM adrenomedullin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CD300A CD300a molecule
CD69 CD69 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP57 centrosomal protein 57kDa
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ENO2 enolase 2 (gamma, neuronal)
FAM13A family with sequence similarity 13, member A
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GOLGA8A golgin A8 family, member A
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PROM1 prominin 1
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK10 serine/threonine kinase 10
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
CD24 CD24 molecule
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
EIF5A eukaryotic translation initiation factor 5A
FLRT3 fibronectin leucine rich transmembrane protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL17RB interleukin 17 receptor B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
RTN1 reticulon 1
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
Funding