BRD-A62182663_YK 4-279_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A62182663_YK 4-279_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
CCND1 cyclin D1
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLGN calmegin
CXCL3 chemokine (C-X-C motif) ligand 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
H2BFS H2B histone family, member S (pseudogene)
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAPTM5 lysosomal protein transmembrane 5
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MUC2 mucin 2, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
S100A12 S100 calcium binding protein A12
SCGB2A1 secretoglobin, family 2A, member 1
SH2B3 SH2B adaptor protein 3
SLA Src-like-adaptor
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TMEM158 transmembrane protein 158 (gene/pseudogene)

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM12 ADAM metallopeptidase domain 12
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARMCX6 armadillo repeat containing, X-linked 6
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
COL5A1 collagen, type V, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
EGF epidermal growth factor
EMP2 epithelial membrane protein 2
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
GTF2A2 general transcription factor IIA, 2, 12kDa
HLA-A major histocompatibility complex, class I, A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
NXT2 nuclear transport factor 2-like export factor 2
OSMR oncostatin M receptor
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1IP1 PDZK1 interacting protein 1
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSU1 Ras suppressor protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SQLE squalene epoxidase
SRP54 signal recognition particle 54kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAGLN2 transgelin 2
TMEM255A transmembrane protein 255A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TRIM16 tripartite motif containing 16
TUFT1 tuftelin 1
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UGP2 UDP-glucose pyrophosphorylase 2
WNT5A wingless-type MMTV integration site family, member 5A