BRD-A62182663_YK 4-279_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-A62182663_YK 4-279_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
GTSE1 G-2 and S-phase expressed 1
HIST1H2BG histone cluster 1, H2bg
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIFC1 kinesin family member C1
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAPD2 non-SMC condensin I complex, subunit D2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TPX2 TPX2, microtubule-associated

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP1 aquaporin 1 (Colton blood group)
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
CTTN cortactin
EFNB2 ephrin-B2
FHL1 four and a half LIM domains 1
GCLC glutamate-cysteine ligase, catalytic subunit
GPX1 glutathione peroxidase 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HP haptoglobin
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IRF7 interferon regulatory factor 7
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SIRT3 sirtuin 3
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBED2 zinc finger, BED-type containing 2
ZSCAN18 zinc finger and SCAN domain containing 18