BRD-A62184259_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A62184259_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ATF3 activating transcription factor 3
BLNK B-cell linker
CA1 carbonic anhydrase I
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN2A cyclin-dependent kinase inhibitor 2A
CNPY3 canopy FGF signaling regulator 3
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
H2BFS H2B histone family, member S (pseudogene)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
IRS1 insulin receptor substrate 1
ISL1 ISL LIM homeobox 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT8 keratin 8, type II
LCN2 lipocalin 2
LPXN leupaxin
MCL1 myeloid cell leukemia 1
MYH10 myosin, heavy chain 10, non-muscle
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCI protein kinase C, iota
RAD23B RAD23 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
SCG2 secretogranin II
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRPS1 trichorhinophalangeal syndrome I
TXNL4B thioredoxin-like 4B
ZNF131 zinc finger protein 131
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
APOD apolipoprotein D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CAST calpastatin
CDC42 cell division cycle 42
DIXDC1 DIX domain containing 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM189B family with sequence similarity 189, member B
FAM57A family with sequence similarity 57, member A
FSTL1 follistatin-like 1
GEMIN4 gem (nuclear organelle) associated protein 4
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
KEAP1 kelch-like ECH-associated protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MCAM melanoma cell adhesion molecule
NDRG2 NDRG family member 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PRDX4 peroxiredoxin 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PWP1 PWP1 homolog (S. cerevisiae)
QPCT glutaminyl-peptide cyclotransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
SUSD5 sushi domain containing 5
TBC1D4 TBC1 domain family, member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WSB2 WD repeat and SOCS box containing 2