BRD-A62184259_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-A62184259_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CHI3L2 chitinase 3-like 2
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DENND5A DENN/MADD domain containing 5A
DLX2 distal-less homeobox 2
EFNA1 ephrin-A1
ENAH enabled homolog (Drosophila)
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MX2 MX dynamin-like GTPase 2
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NKX2-1 NK2 homeobox 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POSTN periostin, osteoblast specific factor
PSPC1 paraspeckle component 1
RAB38 RAB38, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SIRPA signal-regulatory protein alpha
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ANPEP alanyl (membrane) aminopeptidase
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CANT1 calcium activated nucleotidase 1
CIZ1 CDKN1A interacting zinc finger protein 1
COCH cochlin
COLEC12 collectin sub-family member 12
CSK c-src tyrosine kinase
CTBP2 C-terminal binding protein 2
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
EVI2B ecotropic viral integration site 2B
FBXO9 F-box protein 9
FBXW2 F-box and WD repeat domain containing 2
FEN1 flap structure-specific endonuclease 1
FTL ferritin, light polypeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HOMER2 homer scaffolding protein 2
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
LAMC1 laminin, gamma 1 (formerly LAMB2)
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MAT2A methionine adenosyltransferase II, alpha
MBTPS1 membrane-bound transcription factor peptidase, site 1
MLPH melanophilin
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
NELFB negative elongation factor complex member B
NUP62 nucleoporin 62kDa
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
RALBP1 ralA binding protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TMEM164 transmembrane protein 164
TPBG trophoblast glycoprotein
TPST2 tyrosylprotein sulfotransferase 2
TRAK2 trafficking protein, kinesin binding 2
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TWIST1 twist family bHLH transcription factor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
Funding