BRD-A62326914_paroxetine_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A62326914_paroxetine_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACOT9 acyl-CoA thioesterase 9
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
CFB complement factor B
CUX2 cut-like homeobox 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
ELOVL5 ELOVL fatty acid elongase 5
ETNK1 ethanolamine kinase 1
FABP7 fatty acid binding protein 7, brain
FAM134B family with sequence similarity 134, member B
FASN fatty acid synthase
GLRX glutaredoxin (thioltransferase)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HGD homogentisate 1,2-dioxygenase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT8 keratin 8, type II
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MCF2L MCF.2 cell line derived transforming sequence-like
MSMB microseminoprotein, beta-
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPY neuropeptide Y
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PENK proenkephalin
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCD protein kinase C, delta
RAB4A RAB4A, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
SYNGR2 synaptogyrin 2
SYNM synemin, intermediate filament protein
TFF1 trefoil factor 1
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ARHGAP29 Rho GTPase activating protein 29
ATAD2 ATPase family, AAA domain containing 2
BCHE butyrylcholinesterase
BRCA1 breast cancer 1, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CCNE2 cyclin E2
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CXCL13 chemokine (C-X-C motif) ligand 13
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAS1 growth arrest-specific 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GRB10 growth factor receptor-bound protein 10
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KNTC1 kinetochore associated 1
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEIS1 Meis homeobox 1
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG2 non-SMC condensin II complex, subunit G2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
OXCT1 3-oxoacid CoA transferase 1
PCNA proliferating cell nuclear antigen
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RCAN2 regulator of calcineurin 2
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMC2 structural maintenance of chromosomes 2
SNX10 sorting nexin 10
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THY1 Thy-1 cell surface antigen
TMPO thymopoietin
TRIB1 tribbles pseudokinase 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN12 tetraspanin 12
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein
Funding