BRD-A68009927_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-A68009927_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BEX4 brain expressed, X-linked 4
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP5 charged multivesicular body protein 5
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL8A2 collagen, type VIII, alpha 2
CRYZ crystallin, zeta (quinone reductase)
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DYNLT3 dynein, light chain, Tctex-type 3
EGFL6 EGF-like-domain, multiple 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
GLO1 glyoxalase I
GNG10 guanine nucleotide binding protein (G protein), gamma 10
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IGFBP7 insulin-like growth factor binding protein 7
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
KIAA0226L KIAA0226-like
L1CAM L1 cell adhesion molecule
LRRC15 leucine rich repeat containing 15
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MX1 MX dynamin-like GTPase 1
MYO1B myosin IB
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PBX3 pre-B-cell leukemia homeobox 3
PGK1 phosphoglycerate kinase 1
PLS3 plastin 3
PRKCI protein kinase C, iota
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSAD2 radical S-adenosyl methionine domain containing 2
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STS steroid sulfatase (microsomal), isozyme S
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TUBA1A tubulin, alpha 1a
TWF1 twinfilin actin binding protein 1
UGP2 UDP-glucose pyrophosphorylase 2
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VNN1 vanin 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
ARGLU1 arginine and glutamate rich 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC42SE1 CDC42 small effector 1
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
CNOT4 CCR4-NOT transcription complex, subunit 4
CSNK1D casein kinase 1, delta
CST3 cystatin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFHD2 EF-hand domain family, member D2
EFNB2 ephrin-B2
EHD1 EH-domain containing 1
ELANE elastase, neutrophil expressed
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM46A family with sequence similarity 46, member A
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
IER2 immediate early response 2
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUND jun D proto-oncogene
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
LIPG lipase, endothelial
LSG1 large 60S subunit nuclear export GTPase 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MFSD5 major facilitator superfamily domain containing 5
MMP7 matrix metallopeptidase 7
MSL2 male-specific lethal 2 homolog (Drosophila)
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF139 ring finger protein 139
RPL36 ribosomal protein L36
RPL37A ribosomal protein L37a
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
VEZF1 vascular endothelial zinc finger 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZYX zyxin
Funding