BRD-A68281735_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A68281735_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BMP2K BMP2 inducible kinase
BST2 bone marrow stromal cell antigen 2
CD99 CD99 molecule
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DMXL2 Dmx-like 2
DRAM1 DNA-damage regulated autophagy modulator 1
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
GLS glutaminase
GSTP1 glutathione S-transferase pi 1
HEG1 heart development protein with EGF-like domains 1
HEPH hephaestin
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI16 interferon, gamma-inducible protein 16
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITK IL2-inducible T-cell kinase
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LEPR leptin receptor
LY96 lymphocyte antigen 96
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PLAC8 placenta-specific 8
RAP1GAP RAP1 GTPase activating protein
S100A12 S100 calcium binding protein A12
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOCS1 suppressor of cytokine signaling 1
TFEC transcription factor EC
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPCAM epithelial cell adhesion molecule
FABP7 fatty acid binding protein 7, brain
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXG1 forkhead box G1
FRZB frizzled-related protein
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HP haptoglobin
INSM1 insulinoma-associated 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF1A kinesin family member 1A
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LPP LIM domain containing preferred translocation partner in lipoma
MAT2A methionine adenosyltransferase II, alpha
MYO1B myosin IB
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NRN1 neuritin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PLAU plasminogen activator, urokinase
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RBP4 retinol binding protein 4, plasma
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS1 sorbin and SH3 domain containing 1
SST somatostatin
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF544 zinc finger protein 544
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18
Funding