BRD-A68739437_NPK76-II-72-1_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A68739437_NPK76-II-72-1_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
AURKA aurora kinase A
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CCDC92 coiled-coil domain containing 92
CHI3L2 chitinase 3-like 2
CLIC3 chloride intracellular channel 3
CNOT2 CCR4-NOT transcription complex, subunit 2
CRABP2 cellular retinoic acid binding protein 2
DYNLRB1 dynein, light chain, roadblock-type 1
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI27 interferon, alpha-inducible protein 27
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHDC10 kelch domain containing 10
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PDGFC platelet derived growth factor C
PRKCB protein kinase C, beta
PSRC1 proline/serine-rich coiled-coil 1
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SPAG5 sperm associated antigen 5
SUMO3 small ubiquitin-like modifier 3
TAL1 T-cell acute lymphocytic leukemia 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADM adrenomedullin
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
BLNK B-cell linker
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA1 chloride channel accessory 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL15A1 collagen, type XV, alpha 1
CXCL2 chemokine (C-X-C motif) ligand 2
DACT1 dishevelled-binding antagonist of beta-catenin 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGFR epidermal growth factor receptor
EPCAM epithelial cell adhesion molecule
FAM60A family with sequence similarity 60, member A
FAM69A family with sequence similarity 69, member A
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEM GTP binding protein overexpressed in skeletal muscle
GRWD1 glutamate-rich WD repeat containing 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
HOXB6 homeobox B6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP5 insulin-like growth factor binding protein 5
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LOC100505650 uncharacterized LOC100505650
LSP1 lymphocyte-specific protein 1
LTF lactotransferrin
LUM lumican
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
OLFM4 olfactomedin 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PIGR polymeric immunoglobulin receptor
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLXNC1 plexin C1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTCH1 patched 1
PTPRK protein tyrosine phosphatase, receptor type, K
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCD5 stearoyl-CoA desaturase 5
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SORBS2 sorbin and SH3 domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
VCAN versican
VDAC1 voltage-dependent anion channel 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding