BRD-A68930007_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-A68930007_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALOX15B arachidonate 15-lipoxygenase, type B
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL11A1 collagen, type XI, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KTN1 kinectin 1 (kinesin receptor)
LPIN1 lipin 1
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MPO myeloperoxidase
MT1E metallothionein 1E
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-1 NK2 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PKN2 protein kinase N2
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
PTBP2 polypyrimidine tract binding protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RPL37A ribosomal protein L37a
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SFRP4 secreted frizzled-related protein 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG9 sperm associated antigen 9
SRRM2 serine/arginine repetitive matrix 2
SRSF10 serine/arginine-rich splicing factor 10
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAC1 tachykinin, precursor 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53BP2 tumor protein p53 binding protein 2
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YBX1 Y box binding protein 1
ZBED2 zinc finger, BED-type containing 2
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CBR4 carbonyl reductase 4
CCNA2 cyclin A2
CCNF cyclin F
CFB complement factor B
COL6A1 collagen, type VI, alpha 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DIXDC1 DIX domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DUSP4 dual specificity phosphatase 4
FAM57A family with sequence similarity 57, member A
FANCF Fanconi anemia, complementation group F
FEM1B fem-1 homolog b (C. elegans)
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
HMGN4 high mobility group nucleosomal binding domain 4
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
INPP1 inositol polyphosphate-1-phosphatase
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KRT17 keratin 17, type I
LCMT2 leucine carboxyl methyltransferase 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MTCL1 microtubule crosslinking factor 1
NCOR2 nuclear receptor corepressor 2
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PGRMC2 progesterone receptor membrane component 2
PIR pirin (iron-binding nuclear protein)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PTER phosphotriesterase related
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PURA purine-rich element binding protein A
RAB13 RAB13, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
RTP4 receptor (chemosensory) transporter protein 4
SCGB2A1 secretoglobin, family 2A, member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A46 solute carrier family 25, member 46
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
TBC1D16 TBC1 domain family, member 16
TBC1D31 TBC1 domain family, member 31
TFF1 trefoil factor 1
THAP11 THAP domain containing 11
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
WNT5A wingless-type MMTV integration site family, member 5A
Funding