BRD-A69429454_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-A69429454_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BIRC3 baculoviral IAP repeat containing 3
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CHI3L2 chitinase 3-like 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DCN decorin
EIF5A eukaryotic translation initiation factor 5A
FBLN5 fibulin 5
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
JUNB jun B proto-oncogene
LTB lymphotoxin beta (TNF superfamily, member 3)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLAUR plasminogen activator, urokinase receptor
PTGES prostaglandin E synthase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
FBXL12 F-box and leucine-rich repeat protein 12
FGF13 fibroblast growth factor 13
GALC galactosylceramidase
GJA1 gap junction protein, alpha 1, 43kDa
GUSBP3 glucuronidase, beta pseudogene 3
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
KRT6B keratin 6B, type II
MCAM melanoma cell adhesion molecule
PAWR PRKC, apoptosis, WT1, regulator
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)