BRD-A70155556_NP-001236_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

421 genes differentially expressed following the BRD-A70155556_NP-001236_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHR aryl hydrocarbon receptor
ANXA4 annexin A4
ARG2 arginase 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDK14 cyclin-dependent kinase 14
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COG7 component of oligomeric golgi complex 7
COL15A1 collagen, type XV, alpha 1
COL8A2 collagen, type VIII, alpha 2
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP4 FK506 binding protein 4, 59kDa
FRY furry homolog (Drosophila)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FXYD6 FXYD domain containing ion transport regulator 6
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALC galactosylceramidase
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSN gelsolin
GUSBP11 glucuronidase, beta pseudogene 11
H2AFV H2A histone family, member V
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
INSM1 insulinoma-associated 1
IPO13 importin 13
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
IRS1 insulin receptor substrate 1
ISOC1 isochorismatase domain containing 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCTD14 potassium channel tetramerization domain containing 14
KDR kinase insert domain receptor
KIAA1033 KIAA1033
LAPTM4A lysosomal protein transmembrane 4 alpha
LGALS8 lectin, galactoside-binding, soluble, 8
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP12 low density lipoprotein receptor-related protein 12
LY96 lymphocyte antigen 96
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MAP3K7CL MAP3K7 C-terminal like
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MFAP5 microfibrillar associated protein 5
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLPH melanophilin
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
MYO1D myosin ID
NCAM1 neural cell adhesion molecule 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPIPB3 nuclear pore complex interacting protein family, member B3
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
OSBPL10 oxysterol binding protein-like 10
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARVA parvin, alpha
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTHLH parathyroid hormone-like hormone
QPCT glutaminyl-peptide cyclotransferase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RNH1 ribonuclease/angiogenin inhibitor 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNAI2 snail family zinc finger 2
SOX11 SRY (sex determining region Y)-box 11
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCTA T-cell leukemia translocation altered
TESK1 testis-specific kinase 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMCC1 transmembrane and coiled-coil domain family 1
TMEM230 transmembrane protein 230
TMEM30B transmembrane protein 30B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBA1A tubulin, alpha 1a
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP4 aquaporin 4
ATF1 activating transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1S complement component 1, s subcomponent
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBX1 chromobox homolog 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD320 CD320 molecule
CDC123 cell division cycle 123
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLTB clathrin, light chain B
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A2 collagen, type IV, alpha 2
COMMD3 COMM domain containing 3
COMMD4 COMM domain containing 4
CPVL carboxypeptidase, vitellogenic-like
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4A3 eukaryotic translation initiation factor 4A3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXO1 exonuclease 1
EXOSC9 exosome component 9
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM171A1 family with sequence similarity 171, member A1
FAM216A family with sequence similarity 216, member A
FERMT2 fermitin family member 2
FKBP5 FK506 binding protein 5
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GEMIN4 gem (nuclear organelle) associated protein 4
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPB11 heat shock protein family B (small), member 11
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAP2K6 mitogen-activated protein kinase kinase 6
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MICA MHC class I polypeptide-related sequence A
MKI67 marker of proliferation Ki-67
MLF1 myeloid leukemia factor 1
MRPS30 mitochondrial ribosomal protein S30
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFIB nuclear factor I/B
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PKN2 protein kinase N2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
PMEPA1 prostate transmembrane protein, androgen induced 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPIG peptidylprolyl isomerase G (cyclophilin G)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPP30 ribonuclease P/MRP 30kDa subunit
RPS11 ribosomal protein S11
RPS5 ribosomal protein S5
RRAGD Ras-related GTP binding D
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SET SET nuclear proto-oncogene
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TDP1 tyrosyl-DNA phosphodiesterase 1
TECR trans-2,3-enoyl-CoA reductase
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIO trio Rho guanine nucleotide exchange factor
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TTK TTK protein kinase
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WAPAL wings apart-like homolog (Drosophila)
WBSCR22 Williams Beuren syndrome chromosome region 22
ZBTB18 zinc finger and BTB domain containing 18
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