BRD-A70155556_NP-001236_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A70155556_NP-001236_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCK cholecystokinin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DSC2 desmocollin 2
DYNLT3 dynein, light chain, Tctex-type 3
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
F11R F11 receptor
FAM3C family with sequence similarity 3, member C
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD6 frizzled class receptor 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IDS iduronate 2-sulfatase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KIAA0753 KIAA0753
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MELK maternal embryonic leucine zipper kinase
MPZL2 myelin protein zero-like 2
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
P4HB prolyl 4-hydroxylase, beta polypeptide
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RGCC regulator of cell cycle
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1B small proline-rich protein 1B
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TKT transketolase
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
UBE2A ubiquitin-conjugating enzyme E2A
VCAN versican
VLDLR very low density lipoprotein receptor
ZDHHC6 zinc finger, DHHC-type containing 6

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
AKAP8 A kinase (PRKA) anchor protein 8
ASMTL acetylserotonin O-methyltransferase-like
ATP9A ATPase, class II, type 9A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CRYAB crystallin, alpha B
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
KLF9 Kruppel-like factor 9
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFN2 profilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
PVALB parvalbumin
RBP1 retinol binding protein 1, cellular
SCAND1 SCAN domain containing 1
SLA Src-like-adaptor
UGDH UDP-glucose 6-dehydrogenase
VGLL4 vestigial-like family member 4
ZBTB20 zinc finger and BTB domain containing 20
ZIC1 Zic family member 1
Funding