BRD-A70155556_NP-001236_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-A70155556_NP-001236_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APOD apolipoprotein D
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
BLVRB biliverdin reductase B
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
CLCA4 chloride channel accessory 4
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FAM129A family with sequence similarity 129, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD3 FXYD domain containing ion transport regulator 3
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GJA1 gap junction protein, alpha 1, 43kDa
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NEB nebulin
NEFH neurofilament, heavy polypeptide
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL10 oxysterol binding protein-like 10
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PRSS3 protease, serine, 3
PRSS8 protease, serine, 8
PTN pleiotrophin
PYGB phosphorylase, glycogen; brain
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE4 ribonuclease, RNase A family, 4
RRBP1 ribosome binding protein 1
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLAMF7 SLAM family member 7
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNN stannin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STK38 serine/threonine kinase 38
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSPAN1 tetraspanin 1
TTC39A tetratricopeptide repeat domain 39A
TTN titin
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACAT1 acetyl-CoA acetyltransferase 1
ADGRA3 adhesion G protein-coupled receptor A3
ADRB2 adrenoceptor beta 2, surface
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CHPT1 choline phosphotransferase 1
CPVL carboxypeptidase, vitellogenic-like
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
DUT deoxyuridine triphosphatase
EPHA4 EPH receptor A4
FAM216A family with sequence similarity 216, member A
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FN1 fibronectin 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIAA0020 KIAA0020
LIPA lipase A, lysosomal acid, cholesterol esterase
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUP205 nucleoporin 205kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RFC3 replication factor C (activator 1) 3, 38kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
TMEM126B transmembrane protein 126B
TMEM97 transmembrane protein 97
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTR transthyretin
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
WT1 Wilms tumor 1
Funding