BRD-A70155556_NP-001236_VCAP_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-A70155556_NP-001236_VCAP_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
BTG2 BTG family, member 2
C14ORF1 chromosome 14 open reading frame 1
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A5 collagen, type IV, alpha 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
FRY furry homolog (Drosophila)
GDI1 GDP dissociation inhibitor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLK11 kallikrein-related peptidase 11
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LINC00341 long intergenic non-protein coding RNA 341
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL10 oxysterol binding protein-like 10
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
QPCT glutaminyl-peptide cyclotransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERINC5 serine incorporator 5
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TPD52 tumor protein D52
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AQP1 aquaporin 1 (Colton blood group)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BST2 bone marrow stromal cell antigen 2
CCL19 chemokine (C-C motif) ligand 19
CD69 CD69 molecule
CDCA4 cell division cycle associated 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSZ cathepsin Z
DKK1 dickkopf WNT signaling pathway inhibitor 1
FBLN5 fibulin 5
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
NDUFA4 NDUFA4, mitochondrial complex associated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPA3 replication protein A3, 14kDa
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRPG small nuclear ribonucleoprotein polypeptide G
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
THBS1 thrombospondin 1
TPRKB TP53RK binding protein
TSPAN13 tetraspanin 13
Funding