BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_RMUGS_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_RMUGS_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAD8 acyl-CoA dehydrogenase family, member 8
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AIM2 absent in melanoma 2
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD177 CD177 molecule
CD200 CD200 molecule
CD9 CD9 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLDND1 claudin domain containing 1
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FZD6 frizzled class receptor 6
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSPA4 heat shock 70kDa protein 4
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL32 interleukin 32
KRT13 keratin 13, type I
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MSH6 mutS homolog 6
MTERF3 mitochondrial transcription termination factor 3
NAMPT nicotinamide phosphoribosyltransferase
NCK1 NCK adaptor protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCP2 sterol carrier protein 2
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TTC39A tetratricopeptide repeat domain 39A
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
BIRC5 baculoviral IAP repeat containing 5
CDC25B cell division cycle 25B
CHN2 chimerin 2
DCAF7 DDB1 and CUL4 associated factor 7
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM13A family with sequence similarity 13, member A
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GPSM2 G-protein signaling modulator 2
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HMG20B high mobility group 20B
HOXC10 homeobox C10
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
KIF14 kinesin family member 14
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
LRRC16A leucine rich repeat containing 16A
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
NFIB nuclear factor I/B
PLK1 polo-like kinase 1
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VGLL4 vestigial-like family member 4
WNT5A wingless-type MMTV integration site family, member 5A
Funding