BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACADVL acyl-CoA dehydrogenase, very long chain
ACKR3 atypical chemokine receptor 3
AIM2 absent in melanoma 2
APLP2 amyloid beta (A4) precursor-like protein 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD36 CD36 molecule (thrombospondin receptor)
CD83 CD83 molecule
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L2 chitinase 3-like 2
CLU clusterin
CSF1 colony stimulating factor 1 (macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSK cathepsin K
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DMD dystrophin
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP10 dual specificity phosphatase 10
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FN1 fibronectin 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPER1 G protein-coupled estrogen receptor 1
GRAMD3 GRAM domain containing 3
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IFIH1 interferon induced with helicase C domain 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ILK integrin-linked kinase
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
LAMB3 laminin, beta 3
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MREG melanoregulin
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NBPF10 neuroblastoma breakpoint family, member 10
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L3 nuclear factor, erythroid 2-like 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NLRP2 NLR family, pyrin domain containing 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
OPTN optineurin
PDE4DIP phosphodiesterase 4D interacting protein
PELI1 pellino E3 ubiquitin protein ligase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB27A RAB27A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
SCARB2 scavenger receptor class B, member 2
SDC4 syndecan 4
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STAP2 signal transducing adaptor family member 2
STX4 syntaxin 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNIP1 TNFAIP3 interacting protein 1
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACPP acid phosphatase, prostate
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
B3GNT1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF116 chromosome 1 open reading frame 116
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP7 dual specificity phosphatase 7
FAM64A family with sequence similarity 64, member A
FASN fatty acid synthase
FST follistatin
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MRPS30 mitochondrial ribosomal protein S30
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
PDGFA platelet-derived growth factor alpha polypeptide
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PLN phospholamban
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RAP1GAP RAP1 GTPase activating protein
RNF167 ring finger protein 167
SDC1 syndecan 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMTN smoothelin
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
Funding