BRD-A71459254_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-A71459254_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
ALOX15B arachidonate 15-lipoxygenase, type B
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYLD cylindromatosis (turban tumor syndrome)
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DLC1 DLC1 Rho GTPase activating protein
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
EMP1 epithelial membrane protein 1
EZR ezrin
FAM60A family with sequence similarity 60, member A
FKBP14 FK506 binding protein 14, 22 kDa
FNBP1L formin binding protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPGS folylpolyglutamate synthase
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL24 kelch-like family member 24
KLHL7 kelch-like family member 7
KLK5 kallikrein-related peptidase 5
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMP5 lysosomal-associated membrane protein family, member 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NACA nascent polypeptide-associated complex alpha subunit
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFM neurofilament, medium polypeptide
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
NUPL1 nucleoporin like 1
OLFML2A olfactomedin-like 2A
OPHN1 oligophrenin 1
OXSR1 oxidative stress responsive 1
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
PTBP2 polypyrimidine tract binding protein 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RPL10 ribosomal protein L10
RPL17 ribosomal protein L17
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG9 sperm associated antigen 9
SRRM2 serine/arginine repetitive matrix 2
SRSF10 serine/arginine-rich splicing factor 10
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFRC transferrin receptor
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRA2A transformer 2 alpha homolog (Drosophila)
TRH thyrotropin-releasing hormone
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UGCG UDP-glucose ceramide glucosyltransferase
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ANXA6 annexin A6
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL4C ADP-ribosylation factor-like 4C
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
C2ORF68 chromosome 2 open reading frame 68
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CLN5 ceroid-lipofuscinosis, neuronal 5
COL6A1 collagen, type VI, alpha 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DYNLL1 dynein, light chain, LC8-type 1
EIF5A eukaryotic translation initiation factor 5A
FAM178A family with sequence similarity 178, member A
FANCF Fanconi anemia, complementation group F
FCGBP Fc fragment of IgG binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS2 growth arrest-specific 2
GEMIN6 gem (nuclear organelle) associated protein 6
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA5 homeobox A5
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
INTS3 integrator complex subunit 3
IRAK3 interleukin-1 receptor-associated kinase 3
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
LARP1 La ribonucleoprotein domain family, member 1
LCMT2 leucine carboxyl methyltransferase 2
LDAH lipid droplet associated hydrolase
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL13 methyltransferase like 13
MMP7 matrix metallopeptidase 7
MTDH metadherin
MTMR2 myotubularin related protein 2
MUC4 mucin 4, cell surface associated
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPEPPS aminopeptidase puromycin sensitive
NRN1 neuritin 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD54B RAD54 homolog B (S. cerevisiae)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SPTSSA serine palmitoyltransferase, small subunit A
TBC1D31 TBC1 domain family, member 31
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP11 THAP domain containing 11
THYN1 thymocyte nuclear protein 1
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TRIM14 tripartite motif containing 14
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSPAN8 tetraspanin 8
TUBGCP3 tubulin, gamma complex associated protein 3
TXNDC9 thioredoxin domain containing 9
VGLL4 vestigial-like family member 4
WSB2 WD repeat and SOCS box containing 2
ZC3H4 zinc finger CCCH-type containing 4
ZFP64 ZFP64 zinc finger protein
ZMYND8 zinc finger, MYND-type containing 8