BRD-A71459254_CYMARIN_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

264 genes differentially expressed following the BRD-A71459254_CYMARIN_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKHD1 ankyrin repeat and KH domain containing 1
ANKRD11 ankyrin repeat domain 11
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLG1 discs, large homolog 1 (Drosophila)
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FNBP4 formin binding protein 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXJ3 forkhead box J3
FRS2 fibroblast growth factor receptor substrate 2
FTH1 ferritin, heavy polypeptide 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL6 interleukin 6
INHBA inhibin, beta A
ISCA1 iron-sulfur cluster assembly 1
JUN jun proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
NACA nascent polypeptide-associated complex alpha subunit
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NINJ1 ninjurin 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NUPL1 nucleoporin like 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OXSR1 oxidative stress responsive 1
PAWR PRKC, apoptosis, WT1, regulator
PLAGL1 pleiomorphic adenoma gene-like 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNISR PNN-interacting serine/arginine-rich protein
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRC2C proline-rich coiled-coil 2C
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
R3HDM4 R3H domain containing 4
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RND1 Rho family GTPase 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSAD2 radical S-adenosyl methionine domain containing 2
RSRC2 arginine/serine-rich coiled-coil 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRA2B transformer 2 beta homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TTC17 tetratricopeptide repeat domain 17
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZFAND5 zinc finger, AN1-type domain 5
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP5M1 adaptor-related protein complex 5, mu 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASRGL1 asparaginase like 1
ATMIN ATM interactor
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
B3GNT1
BIN1 bridging integrator 1
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
C1ORF115 chromosome 1 open reading frame 115
CADPS2 Ca++-dependent secretion activator 2
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCNG1 cyclin G1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COA3 cytochrome c oxidase assembly factor 3
CPD carboxypeptidase D
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DCPS decapping enzyme, scavenger
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV5 ets variant 5
FADD Fas (TNFRSF6)-associated via death domain
FAM129A family with sequence similarity 129, member A
FANCF Fanconi anemia, complementation group F
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCA grancalcin, EF-hand calcium binding protein
GDI2 GDP dissociation inhibitor 2
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG1 glycogenin 1
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRCC1 lysine-rich coiled-coil 1
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCMT2 leucine carboxyl methyltransferase 2
LDAH lipid droplet associated hydrolase
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MACF1 microtubule-actin crosslinking factor 1
MATN2 matrilin 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLPH melanophilin
MRPL15 mitochondrial ribosomal protein L15
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NEB nebulin
NES nestin
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NRP1 neuropilin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OPN3 opsin 3
PDLIM4 PDZ and LIM domain 4
PNMA1 paraneoplastic Ma antigen 1
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PTPRE protein tyrosine phosphatase, receptor type, E
RHOBTB3 Rho-related BTB domain containing 3
RHOT1 ras homolog family member T1
RNASE4 ribonuclease, RNase A family, 4
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STOML2 stomatin (EPB72)-like 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
THAP11 THAP domain containing 11
THYN1 thymocyte nuclear protein 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM187 transmembrane protein 187
TPD52L1 tumor protein D52-like 1
TRAK2 trafficking protein, kinesin binding 2
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
UBL4A ubiquitin-like 4A
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF32 zinc finger protein 32
Funding