BRD-A73741725_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-A73741725_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTUS1 microtubule associated tumor suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PIR pirin (iron-binding nuclear protein)
S100P S100 calcium binding protein P
SQSTM1 sequestosome 1
TBL1X transducin (beta)-like 1X-linked
TKT transketolase
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
DEFB1 defensin, beta 1
DPT dermatopontin
EMP1 epithelial membrane protein 1
ETNK1 ethanolamine kinase 1
FABP7 fatty acid binding protein 7, brain
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100A6 S100 calcium binding protein A6
SLAMF7 SLAM family member 7
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
TFF3 trefoil factor 3 (intestinal)
WBP5 WW domain binding protein 5