BRD-A73909368_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-A73909368_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
BLNK B-cell linker
BLVRB biliverdin reductase B
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CD200 CD200 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP70 centrosomal protein 70kDa
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFHD1 EF-hand domain family, member D1
EXPH5 exophilin 5
FOLR1 folate receptor 1 (adult)
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GPM6A glycoprotein M6A
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LRRC15 leucine rich repeat containing 15
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NLRP2 NLR family, pyrin domain containing 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLVAP plasmalemma vesicle associated protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SFTPB surfactant protein B
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ANK2 ankyrin 2, neuronal
ARF6 ADP-ribosylation factor 6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRY1 cryptochrome circadian clock 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EGLN1 egl-9 family hypoxia-inducible factor 1
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO2 enolase 2 (gamma, neuronal)
ETV5 ets variant 5
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM208B family with sequence similarity 208, member B
FAM216A family with sequence similarity 216, member A
FAM46A family with sequence similarity 46, member A
FAM69A family with sequence similarity 69, member A
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MTF2 metal response element binding transcription factor 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OGFRL1 opioid growth factor receptor-like 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAD9A RAD9 homolog A (S. pombe)
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RIT1 Ras-like without CAAX 1
RNMT RNA (guanine-7-) methyltransferase
RNMTL1 RNA methyltransferase like 1
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF11 serine/arginine-rich splicing factor 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TNC tenascin C
TNPO1 transportin 1
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZCCHC8 zinc finger, CCHC domain containing 8
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF330 zinc finger protein 330