BRD-A75409952_wortmannin_HCC15_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-A75409952_wortmannin_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD3 abhydrolase domain containing 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD36B ankyrin repeat domain 36B
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL3 B-cell CLL/lymphoma 3
BIK BCL2-interacting killer (apoptosis-inducing)
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EFNA1 ephrin-A1
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
GAS7 growth arrest-specific 7
GDF15 growth differentiation factor 15
GRN granulin
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NUPR1 nuclear protein, transcriptional regulator, 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PSD3 pleckstrin and Sec7 domain containing 3
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RSRP1 arginine/serine-rich protein 1
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TGFBI transforming growth factor, beta-induced, 68kDa
TSC22D3 TSC22 domain family, member 3
TSPO translocator protein (18kDa)
TXNL4B thioredoxin-like 4B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C14ORF169 chromosome 14 open reading frame 169
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
COL15A1 collagen, type XV, alpha 1
COL4A6 collagen, type IV, alpha 6
CYR61 cysteine-rich, angiogenic inducer, 61
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM198B family with sequence similarity 198, member B
FSTL1 follistatin-like 1
GBP1 guanylate binding protein 1, interferon-inducible
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IGF1 insulin-like growth factor 1 (somatomedin C)
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LDHB lactate dehydrogenase B
LUM lumican
MAGEA3 melanoma antigen family A3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP4 microfibrillar-associated protein 4
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NOLC1 nucleolar and coiled-body phosphoprotein 1
NTS neurotensin
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE8B phosphodiesterase 8B
PDZK1 PDZ domain containing 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR2 phosphatase and actin regulator 2
PODXL podocalyxin-like
RBPMS RNA binding protein with multiple splicing
RGS5 regulator of G-protein signaling 5
RHCG Rh family, C glycoprotein
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
STIP1 stress-induced phosphoprotein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGM2 transglutaminase 2
UPK1B uroplakin 1B
WFDC1 WAP four-disulfide core domain 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
ZNF185 zinc finger protein 185 (LIM domain)
Funding