BRD-A75517195_thiazolopyrimidine_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

396 genes differentially expressed following the BRD-A75517195_thiazolopyrimidine_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALAS1 5'-aminolevulinate synthase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BIRC3 baculoviral IAP repeat containing 3
C1ORF27 chromosome 1 open reading frame 27
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
COL16A1 collagen, type XVI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTH cystathionine gamma-lyase
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK5 docking protein 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HAX1 HCLS1 associated protein X-1
HDAC9 histone deacetylase 9
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA9 heat shock 70kDa protein 9 (mortalin)
IARS isoleucyl-tRNA synthetase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MAST4 microtubule associated serine/threonine kinase family member 4
MB myoglobin
MCFD2 multiple coagulation factor deficiency 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
MMP1 matrix metallopeptidase 1
MOCOS molybdenum cofactor sulfurase
MSLN mesothelin
MT1M metallothionein 1M
MYO1D myosin ID
NARS asparaginyl-tRNA synthetase
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PFDN2 prefoldin subunit 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAB32 RAB32, member RAS oncogene family
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSAD2 radical S-adenosyl methionine domain containing 2
SARS seryl-tRNA synthetase
SCG5 secretogranin V
SH3BGR SH3 domain binding glutamate-rich protein
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
THBD thrombomodulin
TMPRSS3 transmembrane protease, serine 3
TNNT1 troponin T type 1 (skeletal, slow)
TRDV3 T cell receptor delta variable 3
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPP1 uridine phosphorylase 1
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZC3H15 zinc finger CCCH-type containing 15
ZFAND1 zinc finger, AN1-type domain 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARHGAP19 Rho GTPase activating protein 19
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAND1 cullin-associated and neddylation-dissociated 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CCNG1 cyclin G1
CD24 CD24 molecule
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLCA2 chloride channel accessory 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSC cathepsin C
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DNM1 dynamin 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GSTA4 glutathione S-transferase alpha 4
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
ICMT isoprenylcysteine carboxyl methyltransferase
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LRP4 low density lipoprotein receptor-related protein 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MPHOSPH9 M-phase phosphoprotein 9
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OXCT1 3-oxoacid CoA transferase 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHACTR4 phosphatase and actin regulator 4
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLP1 proteolipid protein 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PON2 paraoxonase 2
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRMT1 protein arginine methyltransferase 1
PSPH phosphoserine phosphatase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RAB11A RAB11A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SAC3D1 SAC3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SOX2 SRY (sex determining region Y)-box 2
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF2 serine/arginine-rich splicing factor 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TECR trans-2,3-enoyl-CoA reductase
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM194A transmembrane protein 194A
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VCAN versican
WWTR1 WW domain containing transcription regulator 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWINT ZW10 interacting kinetochore protein
Funding