BRD-A75517195_thiazolopyrimidine_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

380 genes differentially expressed following the BRD-A75517195_thiazolopyrimidine_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BPIFA1 BPI fold containing family A, member 1
C1ORF56 chromosome 1 open reading frame 56
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CAST calpastatin
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD84 CD84 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFDP1 craniofacial development protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK4 dedicator of cytokinesis 4
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FGL2 fibrinogen-like 2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2R insulin-like growth factor 2 receptor
IL10RA interleukin 10 receptor, alpha
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
ISOC1 isochorismatase domain containing 1
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LINC00341 long intergenic non-protein coding RNA 341
LPAR6 lysophosphatidic acid receptor 6
LRP12 low density lipoprotein receptor-related protein 12
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PIR pirin (iron-binding nuclear protein)
PLXDC1 plexin domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPAP2C phosphatidic acid phosphatase type 2C
PRRC2C proline-rich coiled-coil 2C
PRTN3 proteinase 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTCA RNA 3'-terminal phosphate cyclase
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SPRY4 sprouty homolog 4 (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STAB1 stabilin 1
STC1 stanniocalcin 1
TACC2 transforming, acidic coiled-coil containing protein 2
TCEAL2 transcription elongation factor A (SII)-like 2
TDO2 tryptophan 2,3-dioxygenase
THBD thrombomodulin
THEMIS2 thymocyte selection associated family member 2
TREM2 triggering receptor expressed on myeloid cells 2
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
UPP1 uridine phosphorylase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ACSF2 acyl-CoA synthetase family member 2
ADAM19 ADAM metallopeptidase domain 19
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF1 activating transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
B3GNT1
BDNF brain-derived neurotrophic factor
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CAND1 cullin-associated and neddylation-dissociated 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNG1 cyclin G1
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CLSTN1 calsyntenin 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB5A cytochrome b5 type A (microsomal)
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DARS aspartyl-tRNA synthetase
DCK deoxycytidine kinase
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DEFB1 defensin, beta 1
DENND5A DENN/MADD domain containing 5A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOK4 docking protein 4
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD1 EH-domain containing 1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM111A family with sequence similarity 111, member A
FLNB filamin B, beta
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLGA8A golgin A8 family, member A
GRSF1 G-rich RNA sequence binding factor 1
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE1 jade family PHD finger 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM4B lysine (K)-specific demethylase 4B
KIF20A kinesin family member 20A
KLF10 Kruppel-like factor 10
KRT10 keratin 10, type I
LAGE3 L antigen family, member 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIMA1 LIM domain and actin binding 1
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MRFAP1L1 Morf4 family associated protein 1-like 1
MSRB2 methionine sulfoxide reductase B2
MTCL1 microtubule crosslinking factor 1
MYLK myosin light chain kinase
NCOA4 nuclear receptor coactivator 4
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NPY neuropeptide Y
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PGRMC2 progesterone receptor membrane component 2
PHACTR2 phosphatase and actin regulator 2
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS23 protease, serine, 23
PRSS3 protease, serine, 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
QKI QKI, KH domain containing, RNA binding
RAB11A RAB11A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCAN1 regulator of calcineurin 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOB ras homolog family member B
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SCP2 sterol carrier protein 2
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SEPT8 septin 8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFPQ splicing factor proline/glutamine-rich
SH3BP4 SH3-domain binding protein 4
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SIAH2 siah E3 ubiquitin protein ligase 2
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SMS spermine synthase
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TMCO3 transmembrane and coiled-coil domains 3
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TNC tenascin C
TOP2B topoisomerase (DNA) II beta 180kDa
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2N ubiquitin-conjugating enzyme E2N
UGCG UDP-glucose ceramide glucosyltransferase
USP48 ubiquitin specific peptidase 48
VCAN versican
WDR61 WD repeat domain 61
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB18 zinc finger and BTB domain containing 18
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