BRD-A75517195_thiazolopyrimidine_HCC515_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-A75517195_thiazolopyrimidine_HCC515_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CECR1 cat eye syndrome chromosome region, candidate 1
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCF2 neutrophil cytosolic factor 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRUNE2 prune homolog 2 (Drosophila)
RAB32 RAB32, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SARS seryl-tRNA synthetase
SERTAD2 SERTA domain containing 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CP ceruloplasmin (ferroxidase)
CYBA cytochrome b-245, alpha polypeptide
DSCC1 DNA replication and sister chromatid cohesion 1
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HEXIM1 hexamethylene bis-acetamide inducible 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCNA proliferating cell nuclear antigen
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SRSF2 serine/arginine-rich splicing factor 2
SST somatostatin
TFRC transferrin receptor
TGM2 transglutaminase 2
TMEM97 transmembrane protein 97
Funding