BRD-A75817871_blebbistatin_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A75817871_blebbistatin_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE5 adhesion G protein-coupled receptor E5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA4 annexin A4
BST2 bone marrow stromal cell antigen 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL10 chemokine (C-X-C motif) ligand 10
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY6E lymphocyte antigen 6 complex, locus E
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OLFM1 olfactomedin 1
ORC1 origin recognition complex, subunit 1
PLSCR1 phospholipid scramblase 1
PSD3 pleckstrin and Sec7 domain containing 3
RSAD2 radical S-adenosyl methionine domain containing 2
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHB Src homology 2 domain containing adaptor protein B
SOD2 superoxide dismutase 2, mitochondrial
SP110 SP110 nuclear body protein
STAT1 signal transducer and activator of transcription 1, 91kDa
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD36 CD36 molecule (thrombospondin receptor)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EDN1 endothelin 1
EGF epidermal growth factor
FKBP14 FK506 binding protein 14, 22 kDa
GADD45B growth arrest and DNA-damage-inducible, beta
HOMER2 homer scaffolding protein 2
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
MAP1B microtubule-associated protein 1B
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OXTR oxytocin receptor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PTCH1 patched 1
RCAN1 regulator of calcineurin 1
RSU1 Ras suppressor protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
Funding