BRD-A77216878_manumycin A_T3M10_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A77216878_manumycin A_T3M10_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL6 B-cell CLL/lymphoma 6
CADM1 cell adhesion molecule 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNL1 cyclin L1
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
CLU clusterin
COCH cochlin
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EAF2 ELL associated factor 2
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL18 interleukin 18
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
MSX1 msh homeobox 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUTF2 nuclear transport factor 2
OSER1 oxidative stress responsive serine-rich 1
PAWR PRKC, apoptosis, WT1, regulator
PCP4 Purkinje cell protein 4
PDZD8 PDZ domain containing 8
PLXNC1 plexin C1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
SLC38A2 solute carrier family 38, member 2
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBPL1 TBP-like 1
THAP11 THAP domain containing 11
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
KIF20A kinesin family member 20A
LAMP3 lysosomal-associated membrane protein 3
LPL lipoprotein lipase
MGLL monoglyceride lipase
MGP matrix Gla protein
MT1E metallothionein 1E
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OASL 2'-5'-oligoadenylate synthetase-like
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLIN1 perilipin 1
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TGOLN2 trans-golgi network protein 2
TSKU tsukushi, small leucine rich proteoglycan
ZBTB18 zinc finger and BTB domain containing 18
Funding