BRD-A79768653_sirolimus_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-A79768653_sirolimus_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCNG2 cyclin G2
CSF1R colony stimulating factor 1 receptor
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FST follistatin
GLUL glutamate-ammonia ligase
HBP1 HMG-box transcription factor 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
JADE2 jade family PHD finger 2
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
MFAP2 microfibrillar-associated protein 2
N4BP2L1 NEDD4 binding protein 2-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUSAP1 nucleolar and spindle associated protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PMM2 phosphomannomutase 2
RAB31 RAB31, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SNX7 sorting nexin 7
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACLY ATP citrate lyase
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CDC6 cell division cycle 6
CPM carboxypeptidase M
DHCR24 24-dehydrocholesterol reductase
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EXOSC8 exosome component 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
G0S2 G0/G1 switch 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
ITGA6 integrin, alpha 6
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
KRT16 keratin 16, type I
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MCM3 minichromosome maintenance complex component 3
MINA MYC induced nuclear antigen
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPL42 mitochondrial ribosomal protein L42
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH9 protocadherin 9
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PNP purine nucleoside phosphorylase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PTRF polymerase I and transcript release factor
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SRM spermidine synthase
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TMX2 thioredoxin-related transmembrane protein 2
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
YARS tyrosyl-tRNA synthetase
Funding