BRD-A79768653_sirolimus_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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59 genes differentially expressed following the BRD-A79768653_sirolimus_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ARID4B AT rich interactive domain 4B (RBP1-like)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C14ORF159 chromosome 14 open reading frame 159
CADPS2 Ca++-dependent secretion activator 2
CLNS1A chloride channel, nucleotide-sensitive, 1A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
HOOK2 hook microtubule-tethering protein 2
IFI27 interferon, alpha-inducible protein 27
MAGED1 melanoma antigen family D1
PDZK1IP1 PDZK1 interacting protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RSRP1 arginine/serine-rich protein 1
SEPP1 selenoprotein P, plasma, 1
SLC35E2B solute carrier family 35, member E2B
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON2 spondin 2, extracellular matrix protein
SYNE2 spectrin repeat containing, nuclear envelope 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AQP3 aquaporin 3 (Gill blood group)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
CD58 CD58 molecule
CDC42SE1 CDC42 small effector 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL4A2 collagen, type IV, alpha 2
CPM carboxypeptidase M
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A eukaryotic translation initiation factor 5A
ELN elastin
FGFR3 fibroblast growth factor receptor 3
FOXD1 forkhead box D1
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPM6A glycoprotein M6A
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
KAT2B K(lysine) acetyltransferase 2B
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC4 mucin 4, cell surface associated
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A2 S100 calcium binding protein A2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
TM4SF1 transmembrane 4 L six family member 1