BRD-A79768653_sirolimus_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A79768653_sirolimus_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BASP1 brain abundant, membrane attached signal protein 1
CCDC92 coiled-coil domain containing 92
CD9 CD9 molecule
CLCA2 chloride channel accessory 2
CLU clusterin
COMT catechol-O-methyltransferase
CORO1A coronin, actin binding protein, 1A
CST3 cystatin C
CTGF connective tissue growth factor
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
HBB hemoglobin, beta
HIST3H2A histone cluster 3, H2a
IGFBP3 insulin-like growth factor binding protein 3
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
LAMA3 laminin, alpha 3
MTSS1 metastasis suppressor 1
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKCH protein kinase C, eta
RAB5B RAB5B, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SH3BGRL SH3 domain binding glutamate-rich protein like
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK26 serine/threonine protein kinase 26
TBX3 T-box 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF3 transmembrane 9 superfamily member 3
TPSAB1 tryptase alpha/beta 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENOPH1 enolase-phosphatase 1
FEN1 flap structure-specific endonuclease 1
GUSBP11 glucuronidase, beta pseudogene 11
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
KIAA0101 KIAA0101
LUM lumican
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCAPG2 non-SMC condensin II complex, subunit G2
NUSAP1 nucleolar and spindle associated protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLK1 polo-like kinase 1
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
STMN2 stathmin 2
TFRC transferrin receptor
TPX2 TPX2, microtubule-associated
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Funding