BRD-A80502530_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-A80502530_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ANPEP alanyl (membrane) aminopeptidase
APOLD1 apolipoprotein L domain containing 1
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
CAST calpastatin
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HOXB2 homeobox B2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
KDM6B lysine (K)-specific demethylase 6B
KLF9 Kruppel-like factor 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OPHN1 oligophrenin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTBP2 polypyrimidine tract binding protein 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB7A RAB7A, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SASH1 SAM and SH3 domain containing 1
SCD5 stearoyl-CoA desaturase 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TSC22D2 TSC22 domain family, member 2
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
BAD BCL2-associated agonist of cell death
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CES1 carboxylesterase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNN1 calponin 1, basic, smooth muscle
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EIF5 eukaryotic translation initiation factor 5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSH6 mutS homolog 6
NSDHL NAD(P) dependent steroid dehydrogenase-like
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPA1 pyrophosphatase (inorganic) 1
PRPF4 pre-mRNA processing factor 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
S100A10 S100 calcium binding protein A10
SLC25A46 solute carrier family 25, member 46
SOX4 SRY (sex determining region Y)-box 4
STEAP3 STEAP family member 3, metalloreductase
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM14A transmembrane protein 14A
TRIM16 tripartite motif containing 16
URI1 URI1, prefoldin-like chaperone
XBP1 X-box binding protein 1
ZNF586 zinc finger protein 586
Funding