BRD-A83124583_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A83124583_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP5 dual specificity phosphatase 5
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL10RA interleukin 10 receptor, alpha
INHBA inhibin, beta A
JMJD6 jumonji domain containing 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RGCC regulator of cell cycle
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BEX1 brain expressed, X-linked 1
CCNF cyclin F
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLTB clathrin, light chain B
COASY CoA synthase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1 insulin-like growth factor 1 (somatomedin C)
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MLEC malectin
MTUS1 microtubule associated tumor suppressor 1
NRIP1 nuclear receptor interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLS3 plastin 3
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UNC13B unc-13 homolog B (C. elegans)
Funding