BRD-A83124583_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-A83124583_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CCDC90B coiled-coil domain containing 90B
CD69 CD69 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EGR4 early growth response 4
EIF5 eukaryotic translation initiation factor 5
FGF2 fibroblast growth factor 2 (basic)
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STK38L serine/threonine kinase 38 like
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CD14 CD14 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CTSH cathepsin H
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
GAS1 growth arrest-specific 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HES1 hes family bHLH transcription factor 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KANK2 KN motif and ankyrin repeat domains 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
MLEC malectin
MLXIP MLX interacting protein
MREG melanoregulin
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYH10 myosin, heavy chain 10, non-muscle
NAV2 neuron navigator 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
PAX5 paired box 5
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNMAL1 paraneoplastic Ma antigen family-like 1
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIN2 Ras and Rab interactor 2
RPL31 ribosomal protein L31
SELENBP1 selenium binding protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
WFDC2 WAP four-disulfide core domain 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF512B zinc finger protein 512B
Funding