BRD-A83326220_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-A83326220_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
APOC1 apolipoprotein C-I
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COG5 component of oligomeric golgi complex 5
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STK17B serine/threonine kinase 17b
STX1A syntaxin 1A (brain)
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TRBC1 T cell receptor beta constant 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ANXA6 annexin A6
ATF5 activating transcription factor 5
CADPS2 Ca++-dependent secretion activator 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CDK14 cyclin-dependent kinase 14
CENPA centromere protein A
CNN1 calponin 1, basic, smooth muscle
COPS7A COP9 signalosome subunit 7A
CPE carboxypeptidase E
DES desmin
DUSP4 dual specificity phosphatase 4
ESR1 estrogen receptor 1
FNBP1 formin binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GTF3A general transcription factor IIIA
HMGN3 high mobility group nucleosomal binding domain 3
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IPO5 importin 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPD1 LY6/PLAUR domain containing 1
MCAM melanoma cell adhesion molecule
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MXRA7 matrix-remodelling associated 7
MYH10 myosin, heavy chain 10, non-muscle
NEFH neurofilament, heavy polypeptide
NUAK1 NUAK family, SNF1-like kinase, 1
PBX1 pre-B-cell leukemia homeobox 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB13 RAB13, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3BP4 SH3-domain binding protein 4
SYNM synemin, intermediate filament protein
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TM7SF3 transmembrane 7 superfamily member 3
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)