BRD-A85860691_chaetocin_LOVO_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-A85860691_chaetocin_LOVO_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSM3 acyl-CoA synthetase medium-chain family member 3
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CD163 CD163 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
CLEC2B C-type lectin domain family 2, member B
CLIP3 CAP-GLY domain containing linker protein 3
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DAD1 defender against cell death 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EFHC1 EF-hand domain (C-terminal) containing 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI30 interferon, gamma-inducible protein 30
IFT27 intraflagellar transport 27
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KYNU kynureninase
LOC100505650 uncharacterized LOC100505650
MAMLD1 mastermind-like domain containing 1
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
NPTX2 neuronal pentraxin II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4B phosphodiesterase 4B, cAMP-specific
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PON3 paraoxonase 3
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRTN3 proteinase 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SHOX2 short stature homeobox 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
ST18 suppression of tumorigenicity 18, zinc finger
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
BCHE butyrylcholinesterase
BCL2L1 BCL2-like 1
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
CAST calpastatin
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFD complement factor D (adipsin)
CFH complement factor H
CLIC3 chloride intracellular channel 3
COG2 component of oligomeric golgi complex 2
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DUSP5 dual specificity phosphatase 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAT1 FAT atypical cadherin 1
FBXO34 F-box protein 34
FLNB filamin B, beta
FOXO3 forkhead box O3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOMER1 homer scaffolding protein 1
HOXB2 homeobox B2
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILK integrin-linked kinase
ISG15 ISG15 ubiquitin-like modifier
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MITF microphthalmia-associated transcription factor
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PCGF2 polycomb group ring finger 2
PEBP1 phosphatidylethanolamine binding protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLN phospholamban
PODXL podocalyxin-like
RAB25 RAB25, member RAS oncogene family
RELN reelin
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMD4A sterile alpha motif domain containing 4A
SCAND1 SCAN domain containing 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMYD2 SET and MYND domain containing 2
SPTBN1 spectrin, beta, non-erythrocytic 1
STAB1 stabilin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TJP2 tight junction protein 2
TP53 tumor protein p53
TRIM14 tripartite motif containing 14
TRIM32 tripartite motif containing 32
TSPAN4 tetraspanin 4
UBE2E1 ubiquitin-conjugating enzyme E2E 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZFPM2 zinc finger protein, FOG family member 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
Funding