BRD-A90451247_KU-60019_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A90451247_KU-60019_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
ALAS1 5'-aminolevulinate synthase 1
ARG1 arginase 1
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
BAD BCL2-associated agonist of cell death
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BPTF bromodomain PHD finger transcription factor
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DCAF7 DDB1 and CUL4 associated factor 7
DDR1 discoidin domain receptor tyrosine kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EPAS1 endothelial PAS domain protein 1
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FRS2 fibroblast growth factor receptor substrate 2
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
GALC galactosylceramidase
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GRK5 G protein-coupled receptor kinase 5
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDE insulin-degrading enzyme
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
JUN jun proto-oncogene
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
LAMA2 laminin, alpha 2
LAMP3 lysosomal-associated membrane protein 3
LTBP1 latent transforming growth factor beta binding protein 1
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MX1 MX dynamin-like GTPase 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NID1 nidogen 1
OLFM4 olfactomedin 4
PAMR1 peptidase domain containing associated with muscle regeneration 1
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRC protein tyrosine phosphatase, receptor type, C
RGS1 regulator of G-protein signaling 1
RSAD2 radical S-adenosyl methionine domain containing 2
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TGFB3 transforming growth factor, beta 3
THBS2 thrombospondin 2
TM9SF3 transmembrane 9 superfamily member 3
TPBG trophoblast glycoprotein
TRAPPC6A trafficking protein particle complex 6A
TUG1 taurine up-regulated 1 (non-protein coding)
WFDC1 WAP four-disulfide core domain 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
CCDC92 coiled-coil domain containing 92
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYTL1 cytokine-like 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLIPR1 GLI pathogenesis-related 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGAV integrin, alpha V
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
NRN1 neuritin 1
PDZK1IP1 PDZK1 interacting protein 1
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PRAME preferentially expressed antigen in melanoma
PRKD3 protein kinase D3
PRPF4 pre-mRNA processing factor 4
PYCR1 pyrroline-5-carboxylate reductase 1
QPCT glutaminyl-peptide cyclotransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SACS sacsin molecular chaperone
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1
Funding