BRD-A93236127_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A93236127_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARFIP2 ADP-ribosylation factor interacting protein 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
CAB39 calcium binding protein 39
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CLTB clathrin, light chain B
CORO1C coronin, actin binding protein, 1C
CST6 cystatin E/M
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYNLT1 dynein, light chain, Tctex-type 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETNK1 ethanolamine kinase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MSX1 msh homeobox 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NUPL1 nucleoporin like 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAB22A RAB22A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF114 ring finger protein 114
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPAG9 sperm associated antigen 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STK17B serine/threonine kinase 17b
STX12 syntaxin 12
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRH thyrotropin-releasing hormone
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
UBE2A ubiquitin-conjugating enzyme E2A
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
B3GNT1
BPIFA1 BPI fold containing family A, member 1
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHGB chromogranin B
CHRDL1 chordin-like 1
COG2 component of oligomeric golgi complex 2
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CTBP1 C-terminal binding protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DIXDC1 DIX domain containing 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FSTL1 follistatin-like 1
GTF3A general transcription factor IIIA
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
LPL lipoprotein lipase
MSLN mesothelin
NDC80 NDC80 kinetochore complex component
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLK1 polo-like kinase 1
PLXND1 plexin D1
PRUNE2 prune homolog 2 (Drosophila)
RAP2A RAP2A, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
TBC1D31 TBC1 domain family, member 31
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176B transmembrane protein 176B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TP53 tumor protein p53
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TUBB tubulin, beta class I
Funding