BRD-A93236127_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-A93236127_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C3 aldo-keto reductase family 1, member C3
AMOTL2 angiomotin like 2
ANXA3 annexin A3
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXIN1 axin 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CCNL1 cyclin L1
CD8A CD8a molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CST6 cystatin E/M
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EREG epiregulin
EZR ezrin
FAM60A family with sequence similarity 60, member A
FGFBP1 fibroblast growth factor binding protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA8 integrin, alpha 8
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC15 leucine rich repeat containing 15
MCL1 myeloid cell leukemia 1
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
NXN nucleoredoxin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BRCA1 breast cancer 1, early onset
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCDC85B coiled-coil domain containing 85B
CHL1 cell adhesion molecule L1-like
COG2 component of oligomeric golgi complex 2
CRISP3 cysteine-rich secretory protein 3
CSK c-src tyrosine kinase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
F12 coagulation factor XII (Hageman factor)
FBXO9 F-box protein 9
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
LTA4H leukotriene A4 hydrolase
MAP2K6 mitogen-activated protein kinase kinase 6
MAT2A methionine adenosyltransferase II, alpha
MATN2 matrilin 2
METTL13 methyltransferase like 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PCYOX1L prenylcysteine oxidase 1 like
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKM pyruvate kinase, muscle
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRR7 proline rich 7 (synaptic)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PURA purine-rich element binding protein A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP3 STEAP family member 3, metalloreductase
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THYN1 thymocyte nuclear protein 1
TRAK2 trafficking protein, kinesin binding 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSPAN8 tetraspanin 8
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
XPOT exportin, tRNA
Funding