BRD-A94377914_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

298 genes differentially expressed following the BRD-A94377914_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY9 adenylate cyclase 9
ADRB2 adrenoceptor beta 2, surface
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ARHGAP32 Rho GTPase activating protein 32
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARL3 ADP-ribosylation factor-like 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX3 armadillo repeat containing, X-linked 3
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNA1 cyclin A1
CCND3 cyclin D3
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CLU clusterin
CORO1A coronin, actin binding protein, 1A
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CSRP1 cysteine and glycine-rich protein 1
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAAM1 dishevelled associated activator of morphogenesis 1
DCN decorin
DGKZ diacylglycerol kinase, zeta
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
ENAH enabled homolog (Drosophila)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FADS3 fatty acid desaturase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KRT23 keratin 23, type I
L1CAM L1 cell adhesion molecule
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAB21L2 mab-21-like 2 (C. elegans)
MAGED1 melanoma antigen family D1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPC1 mitochondrial pyruvate carrier 1
MPC2 mitochondrial pyruvate carrier 2
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MT1E metallothionein 1E
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXRA7 matrix-remodelling associated 7
NAGK N-acetylglucosamine kinase
NCAM1 neural cell adhesion molecule 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NSG1 neuron specific gene family member 1
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
OSBPL8 oxysterol binding protein-like 8
OSTF1 osteoclast stimulating factor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLS1 plastin 1
POR P450 (cytochrome) oxidoreductase
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB40B RAB40B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOC ras homolog family member C
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RTN2 reticulon 2
RTN3 reticulon 3
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAB1 stabilin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VCL vinculin
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP13A3 ATPase type 13A3
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD58 CD58 molecule
CNPY3 canopy FGF signaling regulator 3
DCTD dCMP deaminase
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GTF2I general transcription factor IIi
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MICALL1 MICAL-like 1
MOK MOK protein kinase
MSH6 mutS homolog 6
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMT1 N-myristoyltransferase 1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PARP2 poly (ADP-ribose) polymerase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB13 RAB13, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL37A ribosomal protein L37a
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SCRN1 secernin 1
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG7 sperm associated antigen 7
SPATA5L1 spermatogenesis associated 5-like 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
THBS1 thrombospondin 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
ZBED1 zinc finger, BED-type containing 1