BRD-A94377914_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-A94377914_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ADGRE5 adhesion G protein-coupled receptor E5
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CCL4 chemokine (C-C motif) ligand 4
CCND3 cyclin D3
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COL8A2 collagen, type VIII, alpha 2
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CRABP1 cellular retinoic acid binding protein 1
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
DHCR7 7-dehydrocholesterol reductase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGL2 fibrinogen-like 2
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IRF8 interferon regulatory factor 8
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPT microtubule-associated protein tau
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MXRA7 matrix-remodelling associated 7
NBL1 neuroblastoma 1, DAN family BMP antagonist
NOSIP nitric oxide synthase interacting protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PADI2 peptidyl arginine deiminase, type II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REEP1 receptor accessory protein 1
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
RNF167 ring finger protein 167
ROGDI rogdi homolog (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM6SF1 transmembrane 6 superfamily member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TMEM35 transmembrane protein 35
TMEM41B transmembrane protein 41B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
COCH cochlin
DARS aspartyl-tRNA synthetase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DSP desmoplakin
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPC3 glypican 3
GTF2H5 general transcription factor IIH, polypeptide 5
HDDC2 HD domain containing 2
IGFBP1 insulin-like growth factor binding protein 1
IL1R2 interleukin 1 receptor, type II
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK6 mitogen-activated protein kinase 6
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLA1A phospholipase A1 member A
PLK1 polo-like kinase 1
PRAME preferentially expressed antigen in melanoma
PRDX4 peroxiredoxin 4
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SENP6 SUMO1/sentrin specific peptidase 6
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TOX3 TOX high mobility group box family member 3
TPM4 tropomyosin 4
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
ZHX2 zinc fingers and homeoboxes 2
Funding